von Känel Roland

Group Leader

Prof. Dr. med. Roland von Känel

Platzhalter

Name of the Institution

University Hospital Zurich

Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine
 

Street

Culmannstrasse 8
 

City

8091 Zürich

Phone

+41 44 255 52 51

Group Members

Jürgen Barth, PD Dr. phil., scientific collaborator

Hannes Bielas, Dr. med., scientific collaborator

Joel E. Dimsdale, M.D., Professor, scientific collaborator

Niklaus Egloff, PD Dr. med., scientific collaborator

Igor Grant, M.D., Professor, scientific collaborator

Brigitte M. Kudielka, Prof. Dr. phil., scientific collaborator

Andrés Losada, Ph.D., Professor, scientific collaborator

Leoné Malan, R.N., Ph.D., Professor, scientific collaborator

Brent T. Mausbach, Ph.D., Professor, scientific collaborator

Rebecca E. Meister-Langraf, Dr. phil., scientific collaborator

Monique Pfaltz, Prof. Dr. phil., scientific collaborator

Mary Princip, Dr. phil., scientific collaborator

Joram Ronel, Dr. med., scientific collaborator

Jean-Paul Schmid, Prof. Dr. med., scientific collaborator

Ulrich Schnyder, Prof. Dr. med., scientific collaborator

Kathleen Schwarzkopf, M.Sc., doctoral student

Rebecca C. Thurston, Ph.D., Professor, scientific collaborator

En-Young Nicole Wagner-Cho, Dr. med., scientific collaborator

Petra H. Wirtz, Prof. Dr. phil., scientific collaborator

Hansjörg Znoj, Prof. Dr. phil., scientific collaborator

Main Field(s) of Research / Abstract

Our research activities are focused on 1) the psychobiological (i.e. neurobiological, neuroendocrine, immune, and autonomic nervous system) pathways linking stress and behavior with the development and manifestation of somatic diseases; including atherothrombotic cardiovascular diseases, venous thromboembolism, inflammatory diseases and sleep disorders; 2) the epidemiology, diagnosis, mechanistic models, and treatment of functional somatic symptoms/syndromes and somatic symptom disorders; 3) innovative treatments of patients with comorbid somatic and psychiatric illnesses.

Keywords for Research Field(s)

Anxiety, autonomic nervous system, burnout, behavior, behavioral cardiology, biomarkers, blood coagulation, caregiving, cardiovascular disease, chronic fatigue, chronic pain, cytokines, depression, functional somatic symptoms/syndromes, inflammation, inflammatory bowel disease, job stress, posttraumatic stress disorder, psychobiology, psychocardiology, psychoneuroendocrinology, psychoneuroimmunology, psychosocial stress, psychosomatic medicine, sleep, somatic symptom disorder, stress biology, thrombosis, traumatic stress

Special Techniques and Equipment

We have a fully equipped psychophysiologcal lab for the recording of the activity of the autonomous nervous system (respiration, heart rate, electrodermal activity, EMG, EEG).

Education and Training

We have training opportunities for PhD students, for medical dissertations, for medical master students and for psychology diploma and master students.

Selected Publications

  1. von Känel R, Dimsdale JE. Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Haematol 2000; 65:357-369.
  2. von Känel R, Mills PJ, Fainman C, Dimsdale JE. Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease? Psychosom Med 2001; 63:531-544.
  3. von Känel R, Dimsdale JE, Ziegler MG, Mills PJ, Patterson TL, Lee SK, Grant I. Effect of acute psychological stress on the hypercoagulable state in subjects (spouses of patients with Alzheimer’s disease) with coronary or cerebrovascular disease and/or systemic hypertension. Am J Cardiol 2001; 87:1405-1408.
  4. von Känel R, Mills PJ, Ziegler MG, Dimsdale JE. The effect of b2-adrenergic receptor functioning and increased norepinephrine on the hypercoagulable state with mental stress. Am Heart J 2002; 144:68-72.
  5. von Känel R, Dimsdale JE. Hemostatic alterations in patients with obstructive sleep apnea and the implications for cardiovascular disease. Chest 2003; 124:1956-1967.
  6. von Känel R, Dimsdale JE, Patterson TL, Grant I. Association of negative life-event stress with coagulation activity in elderly Alzheimer caregivers. Psychosom Med 2003; 65:145-150.
  7. von Känel R, Dimsdale JE, Adler KA, Dillon E, Perez C, Mills PJ. Effects of non-specific beta-adrenergic stimulation and blockade on blood coagulation in hypertension. J Appl Physiol 2003; 94:1455-1459.
  8. von Känel R. Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: How strong is the evidence? Acta Psychiatr Scand 2004; 110: 163-177.
  9. von Känel R, Dimsdale JE, Adler KA, Patterson TL, Mills PJ, Grant I. Effects of depressive symptoms and anxiety on hemostatic responses to acute mental stress and recovery in the elderly. Psychiatry Res 2004; 126:253-264.
  10. von Känel R, Kudielka BM, Gander ML, Schulze R, Fischer JE. Hypercoagulability in working men and women with high levels of panic-like anxiety. Psychother Psychosom 2004; 73:353-360.
  11. Grande G, Kümmel M, Struwe C, Jordan J, Schubmann R, Schulze F, Unterberg C, von Känel R, Kudielka BM, Herrmann-Lingen C. Psychother Psychosom Med Psychol 2004; 73:353-360.
  12. von Känel R, Preckel D, Kudielka BM, Haeberli A, Fischer JE. The effect of natural habituation on coagulation responses to acute mental stress and recovery in men. Thromb Haemost 2004; 92:1327-1335.
  13. von Känel R, Kudielka BM, Hanebuth D, Preckel D, Fischer JE. Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation. Clin Sci 2005; 109:61-67.
  14. von Känel R, Kudielka BM, Preckel D, Hanebuth D, Fischer JE. Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men. Brain Behav Immun 2006; 20:40-48.
  15. von Känel R, Dimsdale JE, Ancoli-Israel S, Mills PJ, Patterson TL, Archuleta C, McKibbin CL, Grant I. Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer’s disease. J Am Geriatr Soc 2006; 54:431-437.
  16. von Känel R, Hepp U, Buddeberg C, Keel M, Mica L, Aschbacher K, Schnyder U. Altered blood coagulation in patients with posttraumatic stress disorder. Psychosom Med 2006; 68:598-604.
  17. von Känel R, Dimsdale JE, Mills PJ, Ancoli-Israel S, Patterson TL, Mausbach BT, Grant I. Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimer. J Gerontol A Biol Sci Med Sci 2006; 61:963-969.
  18. Wirtz PH, Ehlert U, Emini L, Ruedisueli K, Groessbauer S, Mausbach B, von Känel R. The role of stress hormones in the relationship between resting blood pressure and coagulation activity. J Hypertens 2006; 24:2409-2416.
  19. Wirtz PH, Ehlert U, Emini L, Ruedisueli K, Groessbauer S, Elsenbruch S, Gaab J, von Känel R. Anticipatory cognitive stress appraisal and the procoagulant stress response in men. Psychosom Med 2006; 68:851-858.
  20. von Känel R, Loredo JS, Ancoli-Israel S, Dimsdale JE. Association between polysomnographic measures of disrupted sleep and prothrombotic factors. Chest 2007; 131:733-739.
  21. von Känel R, Hepp U, Kraemer B, Traber R, Keel M, Mica L, Schnyder U. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res 2007; 41:744-752.
  22. von Känel R. Psychological distress and cardiovascular risk: what are the links? (Editorial) J Am Coll Cardiol 2008; 52:2163-2165.
  23. Hänsel A, von Känel R. The ventro-medial prefrontal cortex: A major link between the autonomic nervous system, regulation of emotion, and stress reactivity? Biopsychosoc Med 2008; 2:21.
  24. von Känel R, Kudielka BM, Metzenthin P, Helfricht S, Preckel D, Haeberli A, Stutz M, Fischer JE. Aspirin, but not propranolol, attenuates the acute-stress induced increase in circulating levels of interleukin-6: a randomized, double-blind, placebo-controlled study. Brain Behav Immun 2008; 22:150-157.
  25. Wiedemar L, Schmid JP, Müller J, Wittmann L, Schnyder U, Saner H, von Känel R. Prevalence and predictors of posttraumatic stress disorder in patients with acute myocardial infarction. Heart Lung 2008; 37:113-121.
  26. von Känel R, Nelesen RA, Mills PJ, Ziegler MG, Dimsdale JE. Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects. Brain Behav Immun 2008; 22:461-468.
  27. Wirtz PH, Bärtschi C, Spillmann M, Ehlert U, von Känel R. Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: a randomized, placebo-controlled study. J Pineal Res 2008; 44:358-365.
  28. von Känel R, Mausbach BT, Patterson TL, Dimsdale JE, Aschbacher K, Mills PJ, Ancoli-Israel S, Grant I. Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controls. Gerontology 2008; 54:131-137.
  29. von Känel R, Bellingrath S, Kudielka BM. Association between burnout and circulating levels of pro- and anti-inflammatory cytokines in school teachers. J Psychosom Res 2008; 65:51-59.
  30. von Känel R, Orth-Gomér K. Autonomic function and prothrombotic activity in women after an acute coronary event. J Womens Health 2008; 17:1331-1337.
  31. Cámara RJ, Ziegler R, Begré S, Schoepfer AM, von Känel R; Swiss Inflammatory Bowel Disease Cohort (SIBDCS) group. The role of psychological stress in inflammatory bowel disease: quality assessment of methods of 18 prospective studies and suggestions for future research. Digestion 2009; 80:129-139.
  32. von Känel R, Kudielka BM, Haeberli A, Stutz M, Fischer JE, Patterson SM. Prothrombotic changes with acute psychological stress: Combined effect of hemoconcentration and genuine coagulation activation. Thromb Res 2009; 123:622-630.
  33. Guler E, Schmid JP, Wiedemar L, Saner H, Schnyder U, von Känel R. Clinical diagnosis of posttraumatic stress disorder after myocardial infarction. Clin Cardiol 2009; 32:125-129.
  34. von Känel R, Barth J, Kohls S, Saner H, Znoj H, Saner G, Schmid JP. Heart rate recovery after exercise in chronic heart failure: Role of vital exhaustion and type D personality. J Cardiol 2009; 53:248-256.
  35. von Känel R, Bellingrath S, Kudielka BM. Association between longitudinal changes in depressive symptoms and plasma fibrinogen levels in school teachers. Psychophysiology 2009; 46:473-480.
  36. Aschbacher K, Roepke SK, von Känel R, Mills PJ, Mausbach BT, Patterson TL, Dimsdale JE, Ziegler MG, Ancoli-Israel S, Grant I. Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers. J Affect Disord 2009; 116:80-87.
  37. Lukas PS, Krummenacher R, Demarmels Biasiutti F, Begré S, Znoj HJ, von Känel R. Association of fatigue and psychological distress with quality of life in patients with a previous venous thromboembolic event. Thromb Haemost 2009; 102:1219-1226.
  38. Abbas CC, Schmid JP, Guler E, Wiedemar L, Begré S, Saner H, Schnyder U, von Känel R.   Trajectory of posttraumatic stress disorder caused by myocardial infarction: a two-year follow-up study. Int J Psychiatry Med 2009; 39:359-376.
  39. Hänsel A, Hong S, Cámara RJ, von Känel R. Inflammation as a psychophysiological biomarker in chronic psychosocial stress. Neurosci Biobehav Rev 2010; 35:115-121.
  40. von Känel R, Schmid JP, Abbas CC, Gander ML, Saner H, Begré S. Stress hormones in patients with posttraumatic stress disorder caused by myocardial infarction and role of comorbid depression. J Affect Disord 2010; 121:73-79.
  41. von Känel R, Begré S, Abbas CC, Saner H, Gander ML, Schmid JP. Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction  and the role of depressive symptoms. Neuroimmunomodulation 2010; 17:39-46.
  42. von Känel R, Kraemer B, Saner H, Schmid JP, Abbas CC, Begré S. Posttraumatic stress disorder and dyslipidemia: previous research and novel findings from patients with PTSD caused by myocardial infarction. World J Biol Psychiatry 2010; 11:141-147.
  43. von Känel R, Natarajan L, Mills PJ, Ancoli-Israel S, Loredo JS, Dimsdale JE. Day/night rhythm of hemostatic factors in obstructive sleep apnea. Sleep 2010; 33:371-377.
  44. Barth J, Schneider S, von Känel R. Lack of social support in the etiology and the prognosisof coronary heart disease: a systematic review and meta-analysis. Psychosom Med 2010; 72:229-238.
  45. Mausbach BT, Roepke SK, Ziegler MG, Milic M, von Känel R, Dimsdale JE, Mills PJ,Patterson TL, Allison, MA, Ancoli-Israel S, Grant I. Association between chronic caregivingstress and impaired endothelial function in the elderly. J Am Coll Cardiol 2010; 55:2599-2606.
  46. Hari R, Begré S, Schmid JP, Saner H, Gander ML, von Känel R. Change over time in posttraumatic stress caused by myocardial infarction and predicting variables. J Psychosom Res 2010; 69:143-150.
  47. von Känel R, Mausbach BT, Dimsdale JE, Mills PJ, Patterson TL, Ancoli-Israel S, Ziegler MG, Roepke SK, Allison M, Grant I. Problem behavior of dementia patients predicts low grade hypercoagulability in spousal caregivers. J Gerontol A Biol Sci Med Sci 2010;      65:1004-1014.
  48. Austin AW, Patterson SM, von Känel R. Hemoconcentration and hemostasis during acute stress: interacting and independent effects. Ann Behav Med 2011; 42:153-173.
  49. Egloff N, Maecker F, Landmann G, von Känel R. Nichtdermatomgebundene somatosensorische Defizite bei chronischen Schmerzpatienten. [Nondermatomal somatosensory deficits in chronic pain patients]. Schmerz 2011; 25:632-642.
  50. von Känel R, Mausbach BT, Dimsdale JE, Mills PJ, Patterson TL, Ancoli-Israel S, Ziegler MG, Roepke SK, Harmell AL, Allison M, Grant I. Regular physical activity moderates cardiometabolic risk in Alzheimer’s caregivers. Med Sci Sports Exerc 2011; 43:181-189.
  51. von Känel R, Carney RM, Zhao S, Whooley MA. Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: Findings from the Heart and Soul Study. Clin Res Cardiol 2011; 100:241-247.
  52. Cámara RJ, Gander ML, Begré S, von Känel R. Posttraumatic stress in Crohn’s Disease and its association with disease activity. Frontline Gastroenterol 2011; 2:2-9.
  53. Cámara RJ, Lukas PS, Begré S, Pittet V, von Känel R; Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) Group. Effects of social support on the clinicalcourse of Crohn’s disease. Inflamm Bowel Dis 2011; 17:1277-1286.
  54. von Känel R, Baumert J, Kolb C, Cho EN, Ladwig KH. Chronic posttraumatic stress and its predictors in patients living with an implantable cardioverter-defibrillator. J Affect Disord 2011; 131:344-352.
  55. von KHari R, Schmid JP, Saner H, Begré S. Distress related to myocardial infarction and cardiovascular outcome: a retrospective observational study. BMC Psychiatry 2011; 11:98.
  56. Cámara RJ, Schoepfer AM, Pittet V, Begré S, von Känel R; Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) Group. Mood and non-mood components of perceived stress and exacerbation of Crohn’s disease. Inflamm Bowel Dis 2011; 17:2358-2365.
  57. von Känel R, Hari R, Schmid JP, Wiedemar L, Guler E, Saner H, Schnyder U, Begré S. Non-fatal cardiovascular outcome in patients with posttraumatic stress symptoms caused by myocardial infarction. J Cardiol 2011; 58:61-68.
  58. von Känel R, Mausbach BT, Dimsdale JE, Mills PJ, Patterson TL, Ancoli-Israel S, Ziegler MG, Roepke SK, Chattillion EA, Allison M, Grant I. Cardiometabolic effects in caregivers of nursing home placement and death of their Alzheimer spouse. J Am Geriatr Soc 2011; 59:2037-2044.
  59. von Känel R. Psychosocial stress and cardiovascular risk – current opinion. Swiss Med Wkly 2012; 142:w13502.
  60. von Känel R, Mausbach BT, Ancoli-Israel S, Dimsdale JE, Mills PJ, Patterson TL, Ziegler MG, Roepke SK, Chattillion EA, Allison M, Grant I. Sleep in spousal Alzheimer caregivers: a longitudinal study with a focus on the effects of major patient transitions on sleep. Sleep 2012; 35:247-255.
  61. Austin AW, Wirtz PH, Patterson SM, Stutz M, von Känel R. Stress-induced alterations in coagulation: Assessment of a new hemoconcentration correction technique. Psychosom Med 2012; 74:288-295.
  62. von Känel R, Mills PJ, Mausbach BT, Dimsdale JE, Patterson TL, Ziegler MG, Ancoli-Israel S, Allison M, Chattillion EA, Grant I. Effect of Alzheimer caregiving on circulating levels of C-reactive protein and other biomarkers relevant to cardiovascular disease risk: a  longitudinal study. Gerontology 2012; 58:354-365.
  63. Egloff N, Maecker F, Stauber S, Sabbioni ME, Tunklova L, von Känel R. Nondermatomalsomatosensorydeficits in chronic pain patients: Are they really hysterical? Pain 2012; 153:1847-1851.
  64. von Känel R, Vökt F, Demarmels Biasiutti F, Stauber S, Wuillemin WA, Lukas PS. Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy. J Thromb Haemost 2012; 10:1547-1555.
  65. Mikocka-Walus A, Andrews JM, von Känel R, Moser G. What are the implications of changing treatment delivery models for inflammatory bowel disease (IBD) sufferers: A discussion paper. Eur J Gastroenterol Hepatol 2013; 25:393-398.
  66. Meister R, Princip M, Schmid JP, Schnyder U, Barth J, Znoj HJ, Herbert C, von Känel R. Myocardial Infarction – Stress PRevention INTervention (MI-SPRINT) to reduce the incidence of posttraumatic stress counseling: study protocol for a randomized controlled trial. Trials 2013; 14:329.
  67. Austin AW, Wissmann T, von Känel R. Stress and hemostasis: an update. Semin Thromb Hemost 2013; 39:902-912.
  68. Egloff N, Hirschi A, von Känel R. Traumatization and chronic pain: a further model of interaction. J Pain Res 2013; 6:765-670.
  69. von Känel R, Natarajan L, Ancoli-Israel S, Mills PJ, Wolfson T, Gamst AC, Loredo JS, Dimsdale JE. Effect of continuous positive airway pressure on day/night rhythm of   prothrombotic markers in obstructive sleep apnea. Sleep Med 2013; 14:58-65.
  70. Hänsel A, von Känel R. Unconscious fearful priming followed by a psychosocial stress test results in higher cortisol levels. Stress Health 2013; 29:317-323.
  71. von Känel R, Hamer M, Malan NT, Scheepers K, Meiring M, Malan L. Prothrombotic reactivity to laboratory acute mental stress in Africans and Caucasians and its relation to depressive symptoms: The SABPA Study. Thromb Haemost 2013; 110:977-986.
  72. Fahrni J, Cho EY-N, Engelberger RP, Baumgartner I, von Känel R. Quality of life in patients with congenital vascular malformations. J Vasc Surg Venous Lymphat Disord 2014; 2:46-51.
  73. von Känel R, Mills PJ, Dimsdale JE, Patterson TL, Ancoli-Israel S, Ziegler MG, Allison M, Chattillion EA, Grant I, Mausbach BT. Longitudinal relationship of low leisure satisfaction but not depressive symptoms with systemic low-grade inflammation in dementia caregivers. J Gerontol B Psychol Sci Soc Sci 2014; 69:397-407.
  74. von Känel R, Mausbach BT, Ancoli-Israel S, Mills PJ, Dimsdale JE, Patterson TL, Grant I. Positive affect and sleep in spousal Alzheimer caregivers: a longitudinal study. Behav Sleep Med 2014; 12:358-372.
  75. Hofer M, Pozzi A, Joray M, Ott R, Leuenberger M, von Känel R, Stanga Z. Safe refeeding management of anorexia nervosa in-patients by an evidence-based protocol. Nutrition 2014; 30:524-530.
  76. Egloff N, Cámara RJ, von Känel R, Klingler N, Marti E, Gander Ferrari ML. Hypersensitivity and hyperalgesia in somatoform pain disorders. Gen Hosp Psychiatry 2014; 36:284-290.
  77. Wirtz PH, von Känel R, Meister R, Arpagaus A, Treichler S, Kuebler U, Huber S, Ehlert U. Dark chocolate intake buffers stress reactivity in humans. J Am Coll Cardiol 2014; 63: 2297-2299.
  78. von Känel R, Müller-Hartmannsgruber V, Kokinogenis G, Egloff N. Vitamin D and central hypersensitivity in chronic pain. Pain Med 2014; 15:1609-1618.
  79. von Känel R, Meister R, Stutz M, Kummer P, Arpagaus A, Huber S, Ehlert U, Wirtz PH. Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men. Thromb Haemost 2014; 112:1151-1158.
  80. von Känel R, Malan NT, Hamer M, van der Westhuizen FH, Malan L. Leukocyte telomere length and hemostatic factors in a South African cohort: The SABPA Study. J Thromb Haemost 2014; 12:1975-1985.
  81. von Känel R. Fear of terror and inflammation ignite heart health decline. (Commentary) Proc Natl Acad Sci USA 2015; 112:1248-1249.
  82. von Känel R. Acute mental stress and hemostasis: when physiology becomes vascular harm. Thromb Res 2015; 135(Suppl. 1):S52-S55.
  83. Pogosova N, Saner H, Pedersen SS, Cupples ME, McGee H, Höfer S, Doyle F, Schmid JP, von Känel R. Psychosocial aspects in cardiac rehabilitation: from theory to practice. A position paper from the Cardiac Rehabilitation Section of the European Association of Prevention and Rehabilitation of the European Society of Cardiology. Eur J Prev Cardiol 2015; 10:1290-1306.
  84. Lindqvist PG, von Känel R. How to avoid venous thromboembolism in women at increased risk - with a special focus on low risk periods. Thromb Res; 2015; 136:513-518.
  85. Meyer FA, Hugentobler E, Stauber S, Willhelm M, Znoj HJ, von Känel R. Depressive symptoms at discharge from rehabilitation predict future cardiovascular-related hospitalizations. Cardiology 2015;131:80-85.
  86. Wagner EY, Wagner JT, Glaus J, Vandeleur CL, Castelao E, Strippoli MP, Vollenweider P, Preisig M, von Känel R. Evidence for low-grade systemic inflammation in individuals with agoraphobia from a population-based prospective study. PLoS One 2015; 10:e0123757
  87. von Känel R, Margani A, Stauber S, Meyer FA, Demarmels Biasiutti F, Vökt F, Wissmann T, Lämmle B, Lukas PS. Depressive symptoms as a novel risk factor for recurrent venous thromboembolism: a longitudinal observational study in patients referred for thrombophilia investigation. PLoS One 2015; 10:e0125858
  88. Princip M, Koemeda M, Meister RE, Barth J, Schnyder U, Znoj HJ, Schmid JP, von Känel R. A picture paints a thousand words: Heart drawings reflect acute distress, illness perception and predict posttraumatic stress symptoms after acute myocardial infarction. Health Psychol Open 2015; January-June:1-10.
  89. von Känel R, Fardad N, Steurer N, Horak N, Hindermann E, Fischer F, Gessler K. Vitamin D status and depressive symptomatology in psychiatric patients hospitalized with a current depressive episode: a factor analytic study. PLoS One 2015; 10:e0138550.
  90. von Känel R. Was der Klinikarzt vom Burnout-Syndrom wissen sollte. Von der gezielten Fragestellung bis zur  Übermittlung der Verdachtsdiagnose. [What the hospitalist needs to know about job burnout - From targeted question to transmission of the suspected diagnosis]. Klinikarzt 2016; 45:26-32.
  91. Egle UT, Egloff N, von Känel R. Stressinduzierte Hyperalgesie (SIH) als Folge von emotionaler Deprivation und psychischer Traumatisierung in der Kindheit. Konsequenzen für die Schmerztherapie. [Stress-induced hyperalgesia (SIH) as a consequence of emotional deprivation and psychosocial traumatization in childhood. Implications for the treatment of chronic pain]. Schmerz 2016; 30:526-536.
  92. von Känel R, Malan N, Hamer M, Lambert GW, Schlaich M, Reimann M, Malan L. Three-year changes of prothrombotic factors in a cohort of South Africans with a high clinical suspicion of obstructive sleep apnea. Thromb Haemost 2016; 115:63-72.
  93. Meister RE, Princip M, Schnyder U, Barth J, Znoj H, Schmid JP, Wittmann L, von Känel R. Association of trait resilience with peritraumatic and posttraumatic stress in patients with myocardial infarction. Psychosom Med 2016; 78:327-334.
  94. Meister R, Weber T, Princip M, Schnyder U, Barth J, Znoj H, Schmid JP, von Känel R.Perception of a hectic hospital environment at admission relates to acute stress disordersymptoms in myocardial infarction patients. Gen Hosp Psychiatry 2016; 39:8-14.
  95. Schwarzkopf K, Conrad N, Straus D, Porschke H, von Känel R. Einmal Burnout ist nicht immer Burnout: Eine stationäre multimodale Psychotherapie ist eine effektive Burnout-Behandlung. [Effectiveness of an inpatient multimodal psychiatric-psychotherapeuticprogram for the treatment of job burnout]. Praxis (Bern 1994) 2016; 105:315-321.
  96. Schwarzkopf K, Straus D, Porschke H, Znoj H, Conrad N, Schmidt-Trucksäss A, von Känel R. Empirical evidence for a relationshipbetween narcissistic personality traits and job burnout. Burn Res 2016; 3:25-33.
  97. Malan L, Hamer M, von Känel R, Schlaich MP, Reimann M, Frasure-Smith N, LambertGW, Vilser W, Harvey BH, Steyn HS, MalanNT. Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study. Nitric Oxide 2016; 55-56:10-17.
  98. Zuccharella-Hackl C, von Känel R, Thomas L, Kuebler P, Schmid JP, Mattle HP, Mono ML, Rieben R, Wiest R, Wirtz PH. Higher macrophage superoxide anion production in coronary artery disease (CAD) patients with TypeD personality. Psychoneuroendocrinology 2016; 68:186-193.
  99. Mikocka-Walus A, Pittet V, Rossel JB, von Känel R; Swiss IBD Cohort Study Group. Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease. Clin Gastroenterol Hepatol 2016;14: 829-835.
  100. Kuebler U, Arpagaus A, Meister RE, von Känel R, Huber S, Ehlert U, Wirtz PH. Darkchocolate attenuates intracellular pro-inflammatory reactivity to acute psychosocial stress inmen: A randomized controlled trial. Brain Behav Immun 2016; 57:200-208.
  101. Thurston RC, Chang Y, Barinas-Mitchell E, Jennings JR, Landsittel DP, Santoro N, von Känel R, Matthews KA. Menopausal hot flashes and carotid intima media thickness among midlife women. Stroke 2016; 47:2910-2915.
  102. von Känel R, van Nuffel M, Fuchs WJ. Risk assessment for job burnout with a mobile health web application using questionnaire data: a proof of concept study. Biopsychosoc Med 2016; 10:31.
  103. Princip M, Scholz M, Meister-Langraf RE, Barth J, Schnyder U, Znoj H, Schmid JP, Thayer JF, von Känel R. Can illness perceptions predict lower heart rate variability following acutemyocardial infarction? Front Psychol 2016; 7:1801.
  104. Edmondson D, von Känel R. Post-traumatic stress disorder and cardiovascular disease. Lancet Psychiatry 2017; 4:320-329.
  105. Pedersen SS, von Känel R, Tully PJ, Denollet J. Psychosocial perspectives in cardiovascular disease. Eur J Prev Cardiol 2017; 24(3_suppl):108-115.
  106. Wirtz PH, von Känel R. Psychological stress, inflammation, and coronary heart disease. Curr Cardiol Rep 2017; 19:111.
  107. Schreiner P, Biedermann L, Rossel JB, Rogler G, Pittet V, von Känel R; Swiss IBD Cohort Study Group. Prevalence and determinants of job stress in patients with inflammatory bowel disease. Inflamm Bowel Dis 2017; 23:310-317.
  108. Thurston RC, Chang Y, Barinas-Mitchell E, von Känel R, Jennings JR, Santoro N, LandsittelDP, Matthews KA. Child abuse and neglect and subclinical cardiovascular disease among midlife women. Psychosom Med 2017; 79:441-449.
  109. von Känel R, Bruwer EJ, Hamer M, de Ridder JH, Malan L. Association between objectively measured physical activity, chronic stress and leukocyte telomere length. J Sports Med Phys Fitness 2017; 57:1349-1358.
  110. Thurston RC, Chang Y, von Känel R, Barinas-Mitchell E, Jennings JR, Hall MH, Santoro N, Buysse DJ, Matthews KA. Sleep characteristics and carotid atherosclerosis among midlife women. Sleep 2017; 40:zsw053.
  111. von Känel R, Herr RM, van Vianen AE, Schmidt B. Association of adaptive and maladaptive narcissism with personal burnout: Findings from a cross-sectional study. Ind Health 2017; 55:233-242.
  112. Pogosova N, Kotseva K, De Bacquer D, von Känel R, De Smedt D, Bruthans J, DolzhenkoM; on behalf of the EUROASPIRE Investigators. Psychosocial risk factors in relation toother cardiovascular risk factors in coronary heart disease: Results from the EUROASPIREIV survey. A registry from the European Society of Cardiology. Eur J Prev Cardiol 2017; 24:1371-1380.
  113. Malan L, Hamer M, von Känel R, Lambert GW, Delport R, Steyn HS, Malan NT. Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point: The SABPA study. Psychoneuroendocrinology 2017; 85:20-27.
  114. Stauber S, Rohrbach T, Saner H, Schmid JP, Grolimund J, von Känel R. . J Clin Psychol Med Settings 2017; 24:376-384.
  115. Imholz L, Meister-Langraf RE, Princip M, Fux M, Schnyder U, Barth J, Znoj H, Schmid JP, von Känel R. Are inflammatory cytokines associated with pain during acutemyocardial infarction? Neuroimmunomodulation 2017; 24:154-161.
  116. Stewart JA, Egloff N, von Känel R, Grolimund J, Studer M, grosse Holtforth M. Motivation for psychologicaltreatment predicts favorable outocomes in multimodal interdisciplinary treatment for chronic somatoform pain.Psychother Psychosom 2017; 86:60-61.
  117. Bielas H, Meister-Langraf RE, Schmid JP, Barth J, Znoj H, Schnyder U, Princip M, von Känel R. Acute stress disorder and C-reactive protein in patients with acute myocardial infarction. Eur  J Prev Cardiol 2018; 25:298-305.
  118. von Känel R, Meister-Langraf RE, Schmid JP, Barth J, Znoj H, Schnyder U, Princip M. Low self-rated health and blood hypercoagulability in patients admitted with acute myocardial infarction. Thromb Haemost 2018; 118:54-62.
  119. Thurston RC, Barinas-Mitchell E, von Känel R, Matthews KA. Trauma exposure and endothelial function among midlife women. Menopause 2018; 25:368-374.
  120. Glaus J, von Känel R, Lasserre AM, Strippoli MF, Vandeleur CL, Castelao E, Gholam- Rezaee M, Marangoni C, Wagner EN, Marques-Vidal P, Waeber G, Vollenweider P, Preisig M, Merikangas KR. Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study. Psychol Med 2018; 48:961-973.
  121. von Känel R, Barth J, Princip M, Meister-Langraf RE, Schmid JP, Znoj H, Herbert C, Schnyder U. Early psychological counseling for the prevention of posttraumatic stress induced by acute coronary syndrome: The MI-SPRINT randomized-controlled trial. Psychother Psychosom 2018; 87:75-84.
  122. Glaus J, von Känel R, Lasserre AM, Strippoli MF, Vandeleur CL, Castelao E, Gholam-Rezaee M, Marangoni C, Wagner EN, Marques-Vidal P, Waeber G, Vollenweider P, PreisigM, Merikangas KR. The bidirectional relationship between anxiety disorders and circulating levels of inflammatory markers: results from a large longitudinal population-based study. Depress Anxiety (in press).
  123. Nowakowski S, Matthews KA, von Känel R, Hall MH, Thurston RC. Sleep characteristicsand inflammatorybiomarkers among midlife women. Sleep (in press).
  124. Bielas H, Meister RE, Schmid JP, Barth J, Znoj H, Schnyder U, Princip M, von Känel R. C-reactive protein as a predictor of posttraumatic stress induced by acute myocardial infarction. Gen Hosp Psychiatry (in press).