Wegener Susanne

Gruppenleiter

Prof. Dr. med. Susanne Wegener

Platzhalter

Institution

University Hospital Zurich
Department of Neurology
 

Strasse/Street

Frauenklinikstrasse 26
 

Ort / City

8091 Zürich

Telefon / Phone

+41-44-255 1111

 

Gruppenmitglieder / Group Members

El Amki, Mohamad Dr. (PhD) Postdoc

Binder, Nadine (PharmMD) PhD student

Herzog, Lisa (Msc) PhD student

Baumgartner, Philipp (cand.med.) Doctoral student

Steffen, Riccardo (cand.med.) Doctoral student

Probst, Jasmin (cand. med.) Doctoral  student

Hamann, Janne (Dr. med.) Physician Scientist

Hauptforschungsgebiet(e) / Main Field(s) of Research / Abstract

Thrombolysis is an effective treatment in acute ischemic stroke. However, the benefit of therapy has to be weighed against the risks, particularly intracerebral hemorrhage. Reasons for a different outcome in stroke may be an individual vulnerability/resistance to ischemia or vascular factors (type of occlusion/collaterals). Using rodent stroke models (MCAO/thrombin injection) and multimodal imaging we are studying mechanisms underlying ischemia tolerance and vascular adaptations to ischemia. Furthermore, we are interested in anatomical and functional correlates of cognitive impairment after MCA-territory stroke (sensorimotor and cognitive testing and Manganese-enhanced MRI). Another project deals with the potential neuroprotective effects of new generation progestins. In a clinical project based on the analysis of patient imaging data, we plan to characterize novel imaging based predictors of therapeutic success in stroke. Our goal is a continuing transfer of knowledge between clinical and experimental stroke research.

Schlüsselwörter für Forschungsgebiet(e) / Keywords for Research Field(s)

ischemic stroke, Magnetic Resonance Imaging, Middle cerebral artery occlusion, preconditioning, post-stroke cognitive impairment, cerebral blood flow, duplex sonography

Ausbildung und Schulung / Education and Training

For interested students, we offer master projects  in the field of clinical and experimental stroke

Wichtigste Publikationen / Selected Publications

1) Schneider J, Sick B, Luft AR, Wegener S. Ultrasound and clinical predictors of recurrent ischemia in symptomatic internal carotid artery occlusion. Stroke 2015 Nov; 46(11):3274-6

2) Bracko O, Di Pietro V, Lazzarino G, Amorini AM, Tavazzi B, Artmann J, Wong  EC, Buxton RB, Weller M, Luft, AR, Wegener S. 3- nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow. J Cereb Blood Flow Metab 2014 Sep; 34(9):1522-30

3) Wegener S, Artmann J, Luft AR, Buxton RB, Weller M, Wong EC. The time of maximum post-ischemic hyperperfusion indicates infarct growth following transient experimental ischemia. PLoS One 2013 May 31; 8(5) e65322

4) Wegener S, Wu WC, Perthen JE, Wong EC. Quantification of rodent cerebral blood flow (CBF) in normal and high flow states using pulsed arterial spin labeling Magnetic Resonance Imaging. JMRI 2007; 26(4):855-862

5) Wegener S, Weber R, Ramos-Cabrer P, Uhlenkueken U, Sprenger C, Wiedermann D, Villringer A, Hoehn M. Temporal profile of T2-weighted MRI distinguishes between pannecrosis and selective neuronal death following transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 2006; 26(1):38-47

6) Wegener S, Gottschalk B, Jovanovic V, Knab R, Fiebach J, Schellinger P, Kucinski T, Jungehülsing GJ, Brunecker P, Müller B, Banasik A, Amberger N, Wernecke KD, Siebler M, Röther J, Villringer A, Weih M. TIAs before ischemic stroke: preconditioning the human brain? A multicenter MRI-study. Stroke 2004; 36(3):616-21

Finanzierung / Funding

Swiss National Science Foundation, Herzstiftung, ESC foundation

URL

http://www.neurologie.usz.ch

Link zur "Forschungsdatenbank" der UZH / Link to the UZH "research database"

http://www.research-projects.uzh.ch/<xxx>.htm