Konrad Daniel

Group Leader

Prof. Dr. med. Daniel Konrad, PhD

Name of the Institution

University Children's Hospital
Department of Endocrinology and Diabetology

Street

Steinwiesstrasse 75

City

8032 Zürich

Phone

+41-44-266 79 66

E-mail

Group Members

Stephan Wüest, PhD (stephan.wueest@usz.ch)
Challa Tenagne Delessa, PhD (TenagneDelessa.Challa@usz.ch)
Fabrizio Lucchini, MSc (fabrizio.lucchini@usz.ch)

Main Field(s) of Research, Abstract

The laboratory focuses on the mechanisms involved in the development of obesity-associated insulin resistance and type 2 diabetes. We developed a novel adipose tissue transplantation paradigm to assess the impact of fat pad localization/venous drainage on glucose homeostasis and insulin sensitivity. Moreover, tissue-specific knockout mice are used to determine the impact of candidate genes in the development of obesity-induced insulin resistance.

Main Fields of Research, Keywords

insulin resistance, obesity, adipose tissue inflammation, type 2 diabetes mellitus

Special Techniques and Equipment

Diverse surgical procedures in mice

Education and Training

Training opportunities for PhD students, PostDocs, Postgraduate Course for Medicine candidates and medical disserations are beeing offered.

Selected Publications

Konrad D, Rudich A, Schoenle EJ. Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue. Diabetologia 2007; 50(4): 833-839.

Wueest S, Rapold RA, Rytka JM, Schoenle EJ, Konrad D. Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high fat-fed mice. Diabetologia 2009; 52(3): 541-546.

Wueest S, Rapold RA, Schumann DM, Rytka JM, Schildknecht A, Chervonsky AV, Rudich A, Schoenle EJ, Donath MY, Konrad D. Fas (CD95) in adipocytes mediates adipose tissue inflammation and contributes to liver and whole-body insulin resistance. J Clin Invest 2010; 120(1): 191-202.

Rytka JM, Wueest S, Schoenle EJ, Konrad D. The portal theory supported by venous drainage-selective fat transplantation. Diabetes 2011; 60(1): 56-63.

Wueest S, Yang X, Liu J, Schoenle EJ, Konrad D. Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice. Am J Physiology Endocrinol Metab 2012; 302(1): E153-160.

Rapold RA, Wueest S, Knoepfel A, Schoenle EJ, Konrad D. Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes. J Lipid Res 2013; 54(1): 63-70.

Wiedemann MSF, Wueest S, Item F, Schoenle EJ, Konrad D. Adipose tissue inflammation contributes to short-term HFD-induced hepatic insulin resistance. Am J Physiology Endocrinol Metab 2013; 305(3): E388-395.

Wueest S, Mueller R, Blüher M, Item F, Chin ASH, Wiedemann MSF, Takizawa H, Kovtonyuk L, Chervonsky AV, Schoenle EJ, Manz MG, Konrad D. Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance. EMBO Mol Med 2014; 6(1): 43-56.

Blüher M, Klöting N, Wueest S, Schoenle EJ, Schön MR, Dietrich A, Fasshauer M, Stumvoll M, Konrad D. Fas and FasL expression in human adipose tissue are related to obesity, insulin resistance and type 2 diabetes. J Clin Endocrinol Metab 2014; 99(1): E36-44.

Wueest S, Item F, Boyle CN, Jirkof P, Cesarovic N, Ellingsgaard H, Böni-Schnetzler M, Timper K, Arras M, Donath MY, Lutz TA, Schoenle EJ, Konrad D. Interleukin-6 contributes to early fasting-induced free fatty acid mobilization in mice. Am J Physiol Regul Integr Comp Physiol 2014; 306(11): R861-867.

Chin SH, Item F, Wueest S, Zhou Z, Wiedemann MSF, Gai Z, Schoenle EJ, Kullak-Ublick GA, Al-Hasani H, Konrad D. Opposing effects of reduced kidney mass on liver and skeletal muscle insulin sensitivity in obese mice. Diabetes 2015; 64(4): 1131-1141.

Wueest S, Item F, Lucchini FC, Challa TD, Müller W, Blüher M, Konrad D. Mesenteric Fat Lipolysis Mediates Obesity-associated Hepatic Steatosis and Insulin Resistance. Diabetes 2015; epub ahead of print.

Funding

Swiss National Science Foundation
European Foundation for the Study of Diabetes
Hartman Müller-Stiftung für Medizinische Forschung
Wolfermann-Nägeli-Stiftung

URL

Link to "Forschungsdatenbank" of the University

not mentioned