Weber Franz

Group Leader

Prof. Dr. rer. nat. Franz E. Weber

Name of the Institution

Dept. of Cranio-Maxillofacial and Oral Surgery
University Hospital Zurich

and

University of Zurich
Center of Dental Medicine

Street

Schönleinstrasse 2

City

8032 Zürich

Phone

+41-44-634 3140

E-mail

Group Members

Chafik Ghayor, PhD, Oberassisten

Nisarat Ruangsawasdi, DDS, MD/PhD student
Tse-Hsiang Chen, PhD student
Bebeka Gjoksi, PhD student
Barbara Siegenthaler, PhD student
Oliver Schätti, PhD-student
Ana Perez, Lab Technician
Alexandre Tchouboukov, Lab-Technician
Yvonne Bloemhard, Lab-Technician

Main Field(s) of Research, Abstract

The laboratory focuses on tissue engineering of bone, pulp and cartilage and is specialized on in situ tissue engineering by using newly developed synthetic andnatural biomimetic materials. In the dental field, beside our pulp regeneration project, we have developed several synthetic and biodegradable guided bone regeneration membranes and have patented the first bioactive degradable guided bone regeneration membrane. Just recently we have unraveled that the bioactivity of these membranes and from the membrane released small chemicals is based on their affinity to bromodomains. Therefore these drugs are epigenetically active. At present wetry to utilize them in clinical applications reaching from bone substitute materials for accelerated bone regeneration to antiresorptive drug for the prevention of osteoporosis.

Main Fields of Research, Keywords

Epigenetics in bone regeneration, osteoconduction, osteoinduction, bone morphogenetic proteins guided bone regeneration, bone regeneration, pulp regeneration, cartilage regeneration , slow release systems for proteins, epigenetically active small chemicals, biomimetic matrices, ECM, tissue engineering, synthetic fibrin, , in vitro bone tissue engineering, surface modification for the attachment of growth factors, anti-resorptive small chemicals, BMP enhancers.

Special Techniques and Equipment

A highly multidisciplinary spectrum of methods is established in the group including 3D-additive manufacturing, molecular biology, animal models, biochemistry, histomorphometry, basic immunological techniques, expression of proteins in E.coli, and the establishment of primary cell cultures including mesenchymal stem cells, periodontal ligament cells, pulp cells, osteoclasts, osteocytes and osteoblasts.

Education and Training

We have training opportunities for PhD students.

Selected Publications

Karfeld-Sulzer L.S., Ghayor C., Siegenthaler B., de Wild M., Leroux J.-C., Weber FE (2015) N-methyl Pyrrolidone/Bone Morphogenetic Protein-2 Double Delivery with In Situ Forming Implants

Journal of Controlled Release. 203C: 181-188.

Gjoksi B., Ghayor C., Siegenthaler B., Roungsawasdi N., Zenobi-Wong M., Weber FE (2015) The epigenetically active small chemical N-Methyl Pyrrolidone (NMP) prevents estrogen depletion induced osteoporosis

Bone 78:114-121.

Ghayor C., Gjoksi B., Siegenthaler B., Weber FE (2015) N-methyl pyrrolidone (NMP) inhibits lipopolysaccharide-induced inflammation by suppressing NF-κB signalling.

Inflammation Res 64: 527-536

Ruangsawasdi, N., Zehnder M., Weber FE (2014) Fibrin Gel Improves Tissue Ingrowth and Cell Differentiation in Human Immature Premolars Implanted in Rats

Journal of Endodontics 40:246-250

Hänseler P., Ehrbar M., Kruse A., Fischer E., Schibli R., Ghayor C., Weber FE (2014) Delivery of BMP-2 by two clinically available apatite materials: In vitro and in vivo comparison.

J Biomed Mater Res A. 2014 Apr 25. doi: 10.1002/jbm.a.35211.

Karfeld-Sulzer LS, Ghayor C., Siegenthaler B., Gjoksi B., Pohjonen TH, Weber FE (2014) Comparative study of NMP preloaded and dip-loaded membranes for guided bone regeneration of rabbit cranial defects.

J Tissue Eng Regen Med. 2014 Jun 12. doi: 10.1002/term.1926

.Hänseler P, Jung UW, Jung RE, Choi KH, Cho KS, Hämmerle CH, Weber F.E. (2012) Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone mineral as delivery systems for glycosylated and non-glycosylated bone morphogenetic protein-2.

Acta Biomater 8:116–123

de Wild, M., Schumacher, R. Mayer, K. Schkommodau, E., Thoma, D., Bredell, M., Kruse -Gujer, A., Grätz, KW, Weber, FE. (2013) Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit

Tissue Engineering Part A: 19 (23-24): 2645-2654

Sala A, Hänseler P, Ranga A, Lutolf MP, Vörös J, Ehrbar M, Weber FE. (2011). Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning. Integr. Biol. 3 (11):1102 – 1111

Ghayor C., Correro R.M., Lange K., Karfeld-Sulzer L.S., Graetz K.W., Weber F.E. (2011) Inhibition of osteoclast differentiation and bone resorption by N-methyl pyrrolidone. J Biol Chem. 286: 24458–24466

Zwahlen R.A., Cheung L.K., Zheng L.-W., Chow R.L.K., Li T., Schuknecht B., Grätz K.W., Weber F.E. (2009) Comparison of two resorbable membrane systems in bone regeneration after removal of wisdom teeth: A randomized controlled clinical pilot study Clin Oral Impl Res 20:1084-1091

San Miguel B., Ghayor Ch, Ehrbar M., Jung R.E., Zwahlen R.A., Hortschansky P., Schmoekel H.G., Weber F.E. (2009) The chemical NMP as a potent BMP enhancer for bone tissue regeneration Tissue Engineering (Part A) 15 (10): 2955-2963

Wechsler S., Fehr D., Molenberg A., Raeber G., Schense J.C., Weber F.E. (2008) A novel, tissue occlusive poly(ethylene glycol) hydrogel material J Biomed. Mat. Res. A A 85A(2):285-292

Lutolf, M.P., Weber, F.E., Schmoekel, H.G., Schense, J.C., Kohler, T., Müller, R. and J.A. Hubbell (2003). Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nature Biotechnol. 21: 513-518

Jung R. E., Glauser R., Schaerer P., Hammerle C.H.F., Sailer H.F., Weber F. E. (2003) The effect of rhBMP-2 on guided bone regeneration in humans. A randomized, controlled clinical and histomorphometric study. Clin. Oral Impl. Res. 14:556-568

Funding

By SNF, CCMX; AO-CMF; EU framework 7, license fees for patents and via service provided on the field of bone repair for industrial partners

URL

Link to "Forschungsdatenbank" of the University

Not mentioned