Felley-Bosco, Emanuela PD

Group Leader

PD Dr. Emanuela Felley-Bosco

 

 

Name of the Institution

Laboratory of Molecular Oncology
Clinic for Oncology
University Hospital Zurich

Street

Zentrum für Klinische Forschung, Sternwartstrasse

Trakt E, Labor 40

City

8091 Zürich

Phone

+41-44-2552771

Fax

E-mail

Group Members

Rossella Parrotta, PhD postdoc; rossella.parrotta@usz.ch
Jelena Kresoja, PhD student; Jelena.rakic@usz.ch
Agata Okonska, PhD student; agata.okonska@usz.ch
Gabriela Ziltener, technician; gabriela.ziltener@usz.ch
Manuel Ronner, apprentice lab technician; manuel.ronner@usz.ch

Main Collaborators

Prof. Dr. W. Weder, Department of Thoracic Surgery, University Hospital Zürich
Prof. H. Moch, Department of Pathology, University Hospital Zürich

Main Field(s) of Research, Abstract

Despite the ban on the commercial use of asbestos in the early nineties, the incidence of malignant pleural mesothelioma in Western Europe will continue to rise over the next decade because of the latency period of up to 40 years. Since the initiation of a multimodality approach including neoadjuvant chemotherapy and extrapleural pneumonectomy, the Clinic for Thoracic Surgery and the Clinic and Policlinic for Oncology at the University Hospital of Zürich have become the major referral center for patients with malignant pleural mesothelioma in Switzerland. The laboratory of Molecular Oncology, belonging to the Clinic and Policlinic for Oncology, has a longtime focus on translational research in thoracic malignancies. Because of the unique opportunity provided by our clinical activities in mesothelioma, we are currently focusing the research efforts of our laboratory in translational and innovative projects in malignant mesothelioma.

•          From asbestos-exposure to cancer: a systemic approach to detect loss of homeostatic control in the mesothelial environment

•          Preclinical Malignant Pleural Mesothelioma Models To Accelerate Clinical Research On Targeted Therapies

Main Fields of Research, Keywords

Mesothelioma therapy, chronic inflammation-induced self-renewal, mesothelioma, cancer stem cells, chemotherapy resistance

Special Techniques and Equipment

Primary and established mesothelioma cell cultures, real-time PCR, apoptosis assays, senescence assay, autophagy assay, cell cycle analysis, transfection techniques, antisense oligonucleotide and siRNA technology, tumour xenograft models.

Education and Training

We have training opportunities for graduate, PhD and MD students interested in the research topics mentioned above.

Funding

SNF, Stiftung für Angewandte Krebsforschung, Krebsliga Zürich, Walter-Bruckerhoff-Stiftung, Baugartenstiftung

URL

Link to "Forschungsdatenbank" of the University