Hersberger Martin

Group Leader

Prof. Dr. Martin Hersberger

Name of the Institution

University Children's Hospital Zürich
Division of Clinical Chemistry and Biochemistry

Street

Steinwiesstrasse 75

City

8032 Zürich

Phone

+41-44-266 75 41

E-mail

Group Members

Bühler Marco, MD Student (marco.buehler@kispi.uzh.ch)
Gemperle Claudio, Technician (claudio.gemperle@kispi.uzh.ch)
Klinke Glynis, PhD Student (glynis.klinke@kispi.uzh.ch)
Marti-Jaun Jacqueline, Technician (jacqueline.marti@kispi.uzh.ch)
Rimann Nicole, Master Student (niciri@hotmail.com)

 

Main Field(s) of Research, Abstract

We are interested in the regulation and in the effect of the resolution of inflammation on chronic inflammatory diseases, like atherosclerosis and asthma. We investigate the genetic regulation and the molecular pathways of enzymes and receptors in these processes. For this we are investigating the role of such enzymes in chronic inflammatory diseases applying genetic approaches in humans and biochemical and molecular approaches in cell culture systems.

Main Fields of Research, Keywords

Atherosclerosis, asthma, anti-inflammation, omega-3 fatty acids, arachidonic acid, lipoxygenases, oxidative stress, risk factors, pro-resolution lipid mediators, adipose tissue inflammation, gene regulation, resolvins, lipoxins

Special Techniques and Equipment

Primary human leukocytes and human adipocytes derived from mesenchymal stem cells. Case-control study for coronary artery disease in collaboration with the Division of Cardiology USZ.

Education and Training

We have training opportunities for PhD and MD students, and for master students in human biology.

Selected Publications

M. Herová, M. Schmid, C. Gemperle, M. Hersberger. ChemR23 the receptor for chemerin and resolvin E1 is expressed and functional on M1 but not on M2 macrophages. J Immunol. 2015 Mar 1;194(5):2330-7.

M. Herová, M. Schmid, C. Gemperle, C. Loretz, M. Hersberger. Low Dose Aspirin is Associated with Plasma Chemerin Levels and May Reduce Adipose Tissue Inflammation. Atherosclerosis. 2014 May 15;235(2):256-262.

SJ. Wuest, T. Horn, J. Marti-Jaun, H. Kühn, M. Hersberger. Association of polymorphisms in the ALOX15B gene with coronary artery disease. Clin Biochem. 2014 Apr;47(6):349-55.

A. Weiss, H. Troxler, G. Klinke, D. Rogler, C. Braegger, M. Hersberger. High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. Lipids Health Dis. 2013 Jun 15;12(1):89.

S. J . Wuest, M. Crucet, C. Gemperle, C. Loretz, M. Hersberger. Expression and regulation of 12/15-lipoxygenases in human primary macrophages. Atherosclerosis. 2012 Nov;225(1):121-7.

V. Waechter, A. Weber, V. Günther, J. Marti-Jaun, M. Herova, M. Schmid, S. Wüst, M. Rösinger, C. Gemperle, M. Hersberger. Characterization of the promoter and the transcriptional regulation of the lipoxin A4 receptor (FPR2/ALX) gene in human monocytes and macrophages. J Immunol. 2012 Feb 15;188(4):1856-67.

J. Wittwer, J. Marti-Jaun and M. Hersberger. A Functional Polymorphism in ALOX15 Results in Increased Allele-Specific Transcription in Macrophages Through Binding of the Transcription Factor SPI1. Hum Mutat. 2006 Jan;27(1):78-87.

Funding

Swiss National Science Foundation, OPO Stiftung, Olga Mayenfisch Stiftung, Hermann-Klaus Stiftung, Georg und Bertha Schwyzer-Winiker Stiftung, EMDO Stiftung, Vontobel Stiftung, Theodor und Ida Herzog-Egli-Stifung

URL

Link to "Forschungsdatenbank" of the University