Wolf Martin
Group Leader
PD Dr. sc. techn. ETH Martin Wolf
Name of the Institution
Biomedical Optics Research Laboratory
Clinic of Neonatology
University Hospital Zurich
Street
Frauenklinikstrasse 10
City
8091 Zürich
Phone
+41-44-255 53 46
Group Members
Andrea Bauschatz, MD, postdoctoral research associate, andrea.bauschatz@usz.ch
Derek Brown, Ph.D., postdoctoral research associate, derek.brown@usz.ch
Jürg Fröhlich, Ph.D. ETHZ, postdoctoral research associate, juerg.froehlich@alumni.ethz.ch
Tanja Karen, MD, postdoctoral research associate, tanja.karen@usz.ch
Geert Morren, Ph.D., postdoctoral research associate, geert.morren@usz.ch
Daniel Haensse, MS ETH, PhD Student, daniel.haensse@usz.ch
Thomas Mühlemann, MS ETH, PhD Student, thomas.muehlemann@usz.ch
Mark Adams, MS ETH, mark.adams@usz.ch
Jean-Claude Fauchère, MD, jean-claude.fauchere@usz.ch
And 3 MS candidates ETH and 2 MD candidates University Zurich
Main Field(s) of Research, Abstract
Medical diagnostics is moving towards non-invasive, portable and inexpensive methods. The Biomedical Optics Research Laboratory (BORL) at the Clinic of Neonatology, University Hospital Zurich is focused on the development of diagnostic tools using light and on the improvement of monitoring systems. The wide field of expertise and research includes:
1. Quantitative near-infrared spectrophotometry (NIRS) and imaging (NIRI), a non-invasive, continuous technique at the bedside, which uses light to analyze tissue. BORL was among the first few groups in this field. The expertise includes the development of instrumentation (sensors, driving electronics, frequency domain and continuous wave systems), software (real time drivers, graphic user interfaces, and post-processing tools) and algorithms (biomedical signal analysis, image reconstruction). BORL successfully invented, developed and clinically applied innovative optical technology to study brain oxygenation, perfusion and function.
2. The development of wireless NIRS systems, where BORL is one of the leading laboratories in the world.
3. The improvement of monitoring systems, i.e. the development of algorithms of artificial intelligence with the aim to analyze the patient’s condition in real time.
4. Clinical testing and research, such as the assessment of muscle and brain function, perfusion and oxygenation and the measurement of tissue composition. One key application is the functional investigation of the brain. The aim is to develop a method to assess the functional severity of brain lesions in adult or neonatal intensive care patients at the bedside. Two types of signals are analyzed: 1. The fast neuronal signal, i.e. the optical changes directly associated with neuronal activity and 2. The slow hemodynamic signal, which reflects a change in hemodynamics indirectly caused by neuronal activity through neurovascular coupling. Both signals can be observed non-invasively through the intact skull. We are using imaging techniques, which allow an online assessment of a whole region of the brain.
Main Fields of Research, Keywords
Functional Near Infrared Spectrophotometry, Brain Function, Oxygenation, Hemodynamics, Neonate, Adult, Intensive Care, Diagnosis
Special Techniques and Equipment
Frequency-Domain Near Infrared Spectrophotometry, Imaging
Wireless systems
Education and Training
We have training opportunities for MD and MS (engineering or natural sciences) students. We are member of the Biomedical Engineering Cluster at the ETHZ (www.bec.ethz.ch).
Selected Publications
Haensse D, Szabo P, Brown D, Fauchère J, Niederer P, Bucher H, Wolf M. A new multichannel near infrared spectrophotometry system for functional studies of the brain in adults and neonates. Opt. Express 2005;13:4525-4538.
Choi JH, Wolf M, Toronov V, Wolf U, Polzonetti C, Hueber D, Safonova LP, Gupta R, Michalos A, Mantulin WW, Gratton E. Noninvasive determination of the optical properties of the adult brain: Near-infrared spectroscopy approach. J. Biomed. Opt. 2004, 9(1): 221-229.
Wolf M, Wolf U, Choi JH, Gupta R, Safonova LP, Paunescu LA, Michalos A, Gratton E. Functional Frequency-domain Near-infrared Spectroscopy Detects Fast Neuronal Signal in the Motor Cortex. Neuroimage 2002, 17: 1868-1875.
Wolf M, Wolf U, Choi JH, Toronov V, Paunescu LA, Michalos A, Gratton E. Fast cerebral functional signal in the 100ms range detected in the visual cortex by frequency-domain near-infrared spectroscopy. Psychophysiology in press.
Wolf U, Wolf M, Choi JH, Paunescu LA, Michalos A, Gratton E. Regional differences of hemodynamics and oxygenation in the human calf muscle detected by near infrared spectrophotometry. Vasc. Surg. in press
Wolf M, Wolf U, Toronov V, Michalos A, Paunescu LA, Choi JH, Gratton E. Different Time Evolution of Oxyhemoglobin and Deoxyhemoglobin Concentration Changes in the Visual and Motor Cortex during Functional Stimulation: A Near Infrared Spectroscopy Study. Neuroimage 2002, 16: 704-712.
Wolf M, von Siebenthal K, Keel M, Dietz V, Baenziger O, Bucher HU. Comparison of Three Methods to Measure Absolute Cerebral Hemoglobin Concentration in Neonates by Near Infrared Spectrophotometry. J Biomed Opt. 2002, 7: 221-227. (was also selected for the April 15, 2002 issue of the Virtual Journal of Biological Physics Research).
Toronov V, Webb A, Choi JH, Wolf M, Michalos A, Gratton E, Hueber D. Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging. Medical Physics 2001, 28(4): 521-527.
Keller E, Wolf M, Martin M Schuknecht B, Yonekawa Y. Estimation of cerebral oxygenation and hemodynamics in cerebral vasospasm using indocyanine green (ICG) dye dilution and near infrared spectroscopy. J Neurosurg Anesthesiol 2001;13(1):43-8.
Wolf M, Duc G, Keel M, Niederer P, von Siebenthal K, Bucher HU. Continuous Noninvasive Measurement of Cerebral Venous Oxygen Saturation at the Bedside in Mechanically Ventilated Neonates. Crit Care Med 1997, 25: 1579-1582.
Funding
SNF, KTI, European Union, University of Zurich, ISS Inc., Herzog-Egli Foundation, Research Foundation Mobile Communication
URL
http://www.neo.unispital.ch/forschung/forschung.htm
Link to "Forschungsdatenbank" of the University
not mentioned