Zentrum für Klinische Forschung

 

Bassetti Claudio

Group Leader

Prof. Dr. med. Claudio Bassetti

Name of the Institution

Department of Neurology
University Hospital of Zurich

Street

Frauenklinikstrasse 26

City

8091 Zürich

Phone

+41-44-255 55 03

E-mail

bassetti claudio@usz.ch

Group Members

Dr. Christian Baumann, MD
Dr. Bo Gao, MD
Dr. Dirk Hermann, MD
Dr. Ramin Khatami, MD
Dr. Ertugul Kilic, MD-PhD
Dr. Ulf Kallweit
Ms. Susan Leemburg, PhD Student
Dr. Rositsa Poryazova, MD
Dr. Max Siccoli, MD
Dr. Ewa Sikierka. MD
Dr. Philipp Valko, MD
Dr. Esther Werth, PhD

Main Field(s) of Research, Abstract

We focus on a basic experimental and clinical approach to study the functions of sleep, the mechanisms underlying sleep disorders and excessive daytime sleepiness. Major fields of interest are 1) sleep dependent plasticity and cognitive functions in healthy subjects and during ischemic stroke recovery. 2) biological markers, sleep-wake regulation and emotional processing in narcolepsy-cataplexy. 3) biological markers and pathophysiology in parasomnia 4) neurobiology of homeostatic and circadian sleep regulation in idiopathic generalized vs. focal epilepsies. Several rodent models of ischemic stroke and sleep manipulation methods are used to investigate dynamic changes during stroke recovery in EEG-defined sleep, multiple intracortical neuronal activity, expression of neuroplasticity-related genes and proteins, and behavioural recovery.

Main Fields of Research, Keywords

Sleep, sleep disorders, excessive daytime sleepiness, narcolepsy-cataplexy, epilepsy, EEG, experimental ischemic stroke, neuroplasticity

Special Techniques and Equipment

Clinical sleep laboratory, human and rodent EEG spectral analysis, molecular biology, rodent behavioural analysis, in vivo rodent ischemia models

Education and Training

Training opportunities for PhD students, PostDocs, medical dissertations and master projects

Selected Publications

Khatami R, Birkmann S, Bassetti CL. Amgydala dysfunction in narcolepsy-cataplexy. J Sleep Res. 2007:16:226-229

Bassetti CL, Hersberger M, Baumann, CR. CSF prostaglandin D synthase is reduced in excessive daytime sleepiness In: Journal of neurology 2006;253, 1030-3

Baumann CR, Kilic E, Petit B, Werth E, Hermann DM, Tafti M, Bassetti CL. Sleep EEG changes after middle cerebral artery infarcts in mice: Different effects of striatal and cortical lesions. Sleep. 2006;29:1339-1344

Baumann CR, Khatami R, Werth E, Bassetti CL. Hypocretin (orexin) deficiency predicts severe objective excessive daytime sleepiness in narcolepsy with cataplexy. J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):402-4.

Kilic U, Kilic E, Jarve A, Guo Z, Spudich A, Bieber K, Barzena U, Bassetti CL, Marti HH, Hermann DM. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J Neurosci. 2006:26:12439-12446.

Khatami R, Maret S, Werth E, Rétey J, Schmid D Maly F Tafti M, Bassetti CL Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathways. Lancet 2004;363(9416):1199-200

Funding

University of Zurich, Forschungsfonds University of Zurich

URL

http://www.neurologie.usz.ch

Link to "Forschungsdatenbank" of the University

http://www.research-projects.unizh.ch/a811.htm