Bassetti Claudio
Group Leader
Prof. Dr. med. Claudio Bassetti
Name of the Institution
Department of Neurology
University Hospital of Zurich
Street
Frauenklinikstrasse 26
City
8091 Zürich
Phone
+41-44-255 55 03
Group Members
Dr. Christian Baumann, MD
Dr. Bo Gao, MD
Dr. Dirk Hermann, MD
Dr. Ramin Khatami, MD
Dr. Ertugul Kilic, MD-PhD
Dr. Ulf Kallweit
Ms. Susan Leemburg, PhD Student
Dr. Rositsa Poryazova, MD
Dr. Max Siccoli, MD
Dr. Ewa Sikierka. MD
Dr. Philipp Valko, MD
Dr. Esther Werth, PhD
Main Field(s) of Research, Abstract
We focus on a basic experimental and clinical approach to study the functions of sleep, the mechanisms underlying sleep disorders and excessive daytime sleepiness. Major fields of interest are 1) sleep dependent plasticity and cognitive functions in healthy subjects and during ischemic stroke recovery. 2) biological markers, sleep-wake regulation and emotional processing in narcolepsy-cataplexy. 3) biological markers and pathophysiology in parasomnia 4) neurobiology of homeostatic and circadian sleep regulation in idiopathic generalized vs. focal epilepsies. Several rodent models of ischemic stroke and sleep manipulation methods are used to investigate dynamic changes during stroke recovery in EEG-defined sleep, multiple intracortical neuronal activity, expression of neuroplasticity-related genes and proteins, and behavioural recovery.
Main Fields of Research, Keywords
Sleep, sleep disorders, excessive daytime sleepiness, narcolepsy-cataplexy, epilepsy, EEG, experimental ischemic stroke, neuroplasticity
Special Techniques and Equipment
Clinical sleep laboratory, human and rodent EEG spectral analysis, molecular biology, rodent behavioural analysis, in vivo rodent ischemia models
Education and Training
Training opportunities for PhD students, PostDocs, medical dissertations and master projects
Selected Publications
Khatami R, Birkmann S, Bassetti CL. Amgydala dysfunction in narcolepsy-cataplexy. J Sleep Res. 2007:16:226-229
Bassetti CL, Hersberger M, Baumann, CR. CSF prostaglandin D synthase is reduced in excessive daytime sleepiness In: Journal of neurology 2006;253, 1030-3
Baumann CR, Kilic E, Petit B, Werth E, Hermann DM, Tafti M, Bassetti CL. Sleep EEG changes after middle cerebral artery infarcts in mice: Different effects of striatal and cortical lesions. Sleep. 2006;29:1339-1344
Baumann CR, Khatami R, Werth E, Bassetti CL. Hypocretin (orexin) deficiency predicts severe objective excessive daytime sleepiness in narcolepsy with cataplexy. J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):402-4.
Kilic U, Kilic E, Jarve A, Guo Z, Spudich A, Bieber K, Barzena U, Bassetti CL, Marti HH, Hermann DM. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J Neurosci. 2006:26:12439-12446.
Khatami R, Maret S, Werth E, Rétey J, Schmid D Maly F Tafti M, Bassetti CL Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathways. Lancet 2004;363(9416):1199-200
Funding
University of Zurich, Forschungsfonds University of Zurich
URL
Link to "Forschungsdatenbank" of the University
http://www.research-projects.unizh.ch/a811.htm